Publications

^* equal contribution, ^# corresponding author

2025

Sven M. Lange^#, Matthew R. McFarland, Frederic Lamoliatte, Thomas Carroll, Logesvaran Krshnan, Anna Perez-Rafols, Dominika Kwasna, Linnan Shen, Iona Wallace, Isobel Cole, Lee A. Armstrong, Axel Knebel, Clare Johnson, Virginia De Cesare, Yogesh Kulathu^# VCP/p97-associated proteins are binders and debranching enzymes of K48-K63-branched ubiquitin chains. Nature Structural & Molecular Biology

Olawale G. Raimi^*, Hina Ojha^*, Kenneth Ehses, Verena Dederer, Sven M. Lange, Cristian Polo Rivera, Tom D. Deegan, Yinchen Chen, Melanie Wightman, Rachel Toth, Karim P. M. Labib, Sebastian Mathea, Neil Ranson, Ruben Fernandez-Busnadiego, Miratul M. K. Muqit^# Mechanism of human PINK1 activation at the TOM complex in a reconstituted system. Science Advances

Lucy Barnsby-Greer, Peter D. Mabbitt, Marc-Andre Dery, Daniel R. Squair, Nicola T. Wood, Frederic Lamoliatte, Sven M. Lange, Satpal Virdee^# UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4. Nature Structural & Molecular Biology

Mateusz Gregorczyk, Graziana Pastore, Ivan Munoz, Thomas Carroll, Johanna Streubel, Meagan Munro, Pawel Lis, Sven M. Lange, Frederic Lamoliatte, Thomas Macartney, Rachel Toth, Fiona Brown, James Hastie, Gislene Pereira, Daniel Durocher, John Rouse^# Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases. Life Science Alliance

Alexia F. Kalogeropulou^*, Elena Purlyte^*, Francesca Tonelli^*, Sven M. Lange, Melanie Wightman, Alan R. Prescott, Shalini Padmanabhan, Esther Sammler, Dario R. Alessi^# Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding. The Biochemical Journal

David Millrine^*, Thomas Cummings^*, Stephen P. Matthews^*, Joshua J. Peter, Helge M. Magnussen, Sven M. Lange, Thomas Macartney, Frederic Lamoliatte, Axel Knebel, Yogesh Kulathu^# Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation. Cell Reports

Syed Arif Abdul Rehman^*^#, Lee A. Armstrong^*, Sven M. Lange, Yosua Adi Kristariyanto, Tobias W. Graewert, Axel Knebel, Dmitri I. Svergun, Yogesh Kulathu^# Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Molecular Cell

Lee A. Armstrong^*, Sven M. Lange^*, Virginia Dee Cesare, Stephen P. Matthews, Raja Sekhar Nirujogi, Isobel Cole, Anthony Hope, Fraser Cunningham, Rachel Toth, Rukmini Mukherjee, Denisa Bojkova, Franz Gruber, David Gray, Paul G. Wyatt, Jindrich Cinatl, Ivan Dikic, Paul Davies, Yogesh Kulathu^# Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. PLOS ONE

Sven M. Lange, Yogesh Kulathu^# Linking K29-Ub chains to biology. Nature Chemical Biology

Mandy Lokaj, Stefanie K. Koesling, Carolin Koerner, Sven M. Lange, Sylvia E.C. Van Beersum, Jeroen Van Reeuwijk, Ronald Roepman, Nicola Horn, Marius Ueffing, Karsten Boldt, Alfred Wittinghofer^# The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. Structure